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Sulodexide is another possible candidate for application in COVID-19 therapy, particularly in patients with a mild form of the disease ( in vitro effects are comparable to enoxaparine, at least in anti-hemostatic effects ( In studies by Gonzalez-Ochoa et al., when compared to a placebo, Sulodexide has been found to possibly reduce the risk of hospitalization and the need for oxygen supply while improving laboratory parameters without increasing the risk of bleeding in early high-risk COVID-19 patients ( In conclusion, a risk of a potential injury of endothelial cells remains months after COVID-19

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In summary, we demonstrated that decreased GPx1 is involved in the induction of protective autophagy and is regulated by glycolysis inhibition in PDA cells upon glucose deprivation (Fig